Side Effects From Leptospirosis Vaccine. The most common canine lepto vaccine, nobivac/versican plus l4, is a veterinary vaccine that contains inactivated (killed) strains of leptospira bacteria. In addition, side effects of the vaccine can cause painful swelling.
However, please keep in mind that the leptospirosis vaccine is most commonly associated with. Local reactions include pain, swelling, abscesses, redness and irritation. Occurs when dogs come into contact with infected urine or ingest infected tissue.