How Do You Know If Your Great Dane Is Pregnant. If you spy swelling on your pet, which for a pregnant great dane will occur by the fourth week of pregnancy, the veterinarian will palpate or press the area. If the vet tells you she is pregnant, i would suggest that you get cracking now on learning all the things that you haven't learned about breeding.
If you own a pregnant great dane, you’ll want to inform yourself before she delivers to prepare yourself for the litter! This testing alone could cause some pretty high vet bills. For maiden bitches with an average litter size, you usually cannot see that they are pregnant till around 6 weeks (and even than is hard to tell for sure), for bitches who have whelped before, i can tell at just over 2 weeks.